Analysis of X-ray-induced aberrations in human chromosome 5 using high-resolution multicolour banding FISH (mBAND)

被引：39
|
作者：
Johannes, C
Chudoba, I
Obe, G
机构：
[1] Univ Essen Gesamthsch, Dept Genet, D-45117 Essen, Germany
[2] MetaSyst, D-68804 Altlussheim, Germany
来源：
CHROMOSOME RESEARCH | 1999年 / 7卷 / 08期
关键词：
chromosomal aberrations; human chromosome 5; mBAND; X-irradiation;
D O I：
10.1023/A:1009284018942
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peripheral lymphocytes were exposed to 4 Gy X-rays and aberrations were analysed in human chromosome 5 using high-resolution multicolour banding fluorescence in-situ hybridization (mBAND). This method is suited to detect simple and complex aberrations including peri- and paracentric inversions and exchanges between both chromosomes 5. Additionally, breakpoints can be assigned to specific regions in chromosome 5. Quantitative relationships of induced aberration types are discussed.
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页码：625 / 633
页数：9
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