Development of inactivated poliovirus vaccine derived from Sabin strains

被引：39

作者：

Simizu, B ^{[1
]}

Abe, S ^{[1
]}

Yamamoto, H ^{[1
]}

Tano, Y ^{[1
]}

Ota, Y ^{[1
]}

Miyazawa, M ^{[1
]}

Horie, H ^{[1
]}

Satoh, K ^{[1
]}

Wakabayashi, K ^{[1
]}

机构：

[1] Japan Poliomyelitis Res Inst, Tokyo 1890003, Japan

来源：

BIOLOGICALS | 2006年 / 34卷 / 02期

关键词：

IPV; Sabin strains; D-antigen; immunogenicity;

D O I：

10.1016/j.biologicals.2006.02.010

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In the course of Sabin-inactivated poliovirus vaccine (S-IPV) development, we have established high-yield virus production techniques based on Vero cell micro-carrier cultures. Development of specific ELISA tests to quantify the antigen content of S-IPV has been achieved. To adjust the immunogenicity of S-IPV so as to be comparable with the conventional-IPV, a new formulation was determined using a potency test using rats. The reformulated S-IPV was shown to be efficacious for the immunization of monkeys. (c) 2006 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.

引用

页码：151 / 154

页数：4

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