Effects of multi-mode physical stimulation on APP/PS1 Alzheimer's disease model mice

被引：5
|
作者：
Liu, Shupeng [1 ,2 ]
Li, Shuyang [1 ,2 ]
Xia, Yudan [1 ,2 ]
Zhang, Heng [1 ,2 ]
Tian, Jing [3 ]
Shan, Chunlei [4 ]
Pang, Fufei [1 ,2 ]
Wang, Ying [5 ]
Shang, Yana [1 ,2 ]
Chen, Na [1 ,2 ]
机构：
[1] Shanghai Univ, Shanghai Inst Adv Commun & Data Sci, Key Lab Specialty Fiber Opt, Shanghai 200444, Peoples R China
[2] Shanghai Univ, Shanghai Inst Adv Commun & Data Sci, Opt Access Networks, Shanghai 200444, Peoples R China
[3] Southeast Univ, Sch Electron & Comp, Chengxian Coll, Nanjing 210088, Peoples R China
[4] Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, Shanghai 201203, Peoples R China
[5] Fudan Univ, Sch Publ Hlth, Shanghai 200032, Peoples R China
来源：
HELIYON | 2022年 / 8卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; Amyloid; rhythm; APP; PS1; Multimodal physical stimulation; PRECURSOR PROTEIN APP; MORRIS WATER MAZE; COGNITIVE IMPAIRMENT; PHOTIC-STIMULATION; MOUSE MODEL; PHOTOBIOMODULATION; NEURODEGENERATION; ENTRAINMENT; MECHANISMS; DEMENTIA;
D O I：
10.1016/j.heliyon.2022.e12366
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Some researchers and clinics have reported that non-drug treatments for Alzheimer disease (AD) such as electrical stimulation, light stimulation, music stimulation, laser stimulation, and transcranial magnetic stimulation may have beneficial treatment effects. Following these findings, in this study, we performed multimodel physical stimulation on APP/PS1 mice using visible light, music with a gamma rhythm, and an infrared laser. And the effects of physical stimulation on APP/PS1 mice were evaluated by behavioral analysis, the content of amyloid (A beta 40 and A beta 42), and NISSL staining of hippocampal tissue slices. The results of subsequent behavioral and tissue analyses showed that the multi-model physical stimulations could relieve APP/PS1 mice's dementia symptoms, such as the behavior ability, the content of A beta 40 and A beta 42 in the hippocampal tissue suspension, and Nissl staining for hippocampal tissue analyses.
引用
收藏
页数：10
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