A regulatory role for complement in innate immunity and autoimmunity

被引：51
|
作者：
Nauta, AJ [1 ]
Roos, A [1 ]
Daha, MR [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Nephrol, NL-2333 ZA Leiden, Netherlands
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2004年 / 134卷 / 04期
关键词：
complement; apoptosis; autoimmunity; receptors; dendritic cells;
D O I：
10.1159/000079261
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
The complement system comprises a strong defense against various pathogens and is a major component of our innate immune system. While earlier studies have established a crucial role of complement in recognition, opsonization and enhanced phagocytosis of microorganisms by professional phagocytes such as polymorphonuclear leukocytes and macrophages, recent studies delineate an additional role of complement in initiation and maintenance of the acquired immune response. In addition, it seems that opsonization of apoptotic cells by complement may lead to polarization of the response of professional antigen-presenting cells to a more inflammatory or tolerogenic response. The present review summarizes these different contributions of complement to the shaping of the immune balance. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码：310 / 323
页数：14
相关论文
共 50 条
  • [31] Putting the brakes on innate immunity: a regulatory role for CD200?
    Nathan, C
    Muller, WA
    NATURE IMMUNOLOGY, 2001, 2 (01) : 17 - 19
  • [32] The regulatory role of NLRX1 in innate immunity and human disease
    Liu, Minqi
    Liu, Kexuan
    Cheng, Di
    Zheng, Biao
    Li, Shan
    Mo, Zhongcheng
    CYTOKINE, 2022, 160
  • [33] A role for complement in the regulation of autoimmunity
    Agyemang, Amma F.
    Tsiftsoglou, Stephanos A.
    Alimzhanov, Marat B.
    Imanishi-Kari, Thereza
    Carroll, Michael C.
    MOLECULAR IMMUNOLOGY, 2008, 45 (16) : 4141 - 4142
  • [34] The role of complement in innate and adaptive immunity to pneumococcal colonization and sepsis in a murine model
    Bogaert, D.
    Thompson, C. M.
    Trzcinski, K.
    Malley, R.
    Lipsitch, M.
    VACCINE, 2010, 28 (03) : 681 - 685
  • [35] Gene regulatory mechanisms in innate immunity
    Maniatis, T.
    FEBS JOURNAL, 2008, 275 : 4 - 4
  • [36] Early phases of complement activation and innate immunity
    Loos, M
    SHOCK, 2004, 21 : 7 - 7
  • [37] Innate immunity and protective neuroinflammation: New emphasis on the role of neuroimmune regulatory proteins
    Griffiths, M.
    Neal, J. W.
    Gasque, P.
    NEUROINFLAMMATION IN NEURONAL DEATH AND REPAIR, 2007, 82 : 29 - 55
  • [38] Regulatory role of nitric oxide in lipopolysaccharides-triggered plant innate immunity
    Sun, Aizhen
    Li, Zhe
    PLANT SIGNALING & BEHAVIOR, 2013, 8 (01) : 134 - 136
  • [39] A dual regulatory role of Arabidopsis calreticulin-2 in plant innate immunity
    Qiu, Yongjian
    Xi, Jing
    Du, Liqun
    Roje, Sanja
    Poovaiah, B. W.
    PLANT JOURNAL, 2012, 69 (03): : 489 - 500
  • [40] Role of complement as shared effector system between innate and adaptive immunity in teleost fish
    Lorenzo, G
    Gerstein, A
    Boshra, H
    Sunyer, JO
    JOURNAL OF LEUKOCYTE BIOLOGY, 2000, : 11 - 11
12345