Genetic and Environmental Influences on Semantic Verbal Fluency Across Midlife and Later Life

被引:5
|
作者
Gustavson, Daniel E. [1 ,2 ,3 ]
Panizzon, Matthew S. [2 ,3 ]
Kremen, William S. [2 ,3 ,4 ]
Reynolds, Chandra A. [5 ]
Pahlen, Shandell [5 ]
Nygaard, Marianne [6 ]
Wod, Mette [6 ]
Catts, Vibeke S. [7 ]
Lee, Teresa [7 ]
Gatz, Margaret [8 ,9 ]
Franz, Carol E. [2 ,3 ]
机构
[1] Vanderbilt Univ, Med Ctr, Vanderbilt Genet Inst, Dept Med, 1420B Med Ctr East, Nashville, TN 37232 USA
[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Ctr Behav Genet Aging, La Jolla, CA 92093 USA
[4] VA Ctr Excellence Stress & Mental Hlth, La Jolla, CA USA
[5] Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA
[6] Univ Southern Denmark, Danish Twin Registry, Dept Publ Hlth, Odense C, Denmark
[7] Univ New South Wales Sydney, Sch Psychiat, Ctr Healthy Brain Ageing, Sydney, NSW, Australia
[8] Univ Southern Calif, Ctr Econ & Social Res, Los Angeles, CA 90007 USA
[9] Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden
基金
澳大利亚研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会; 美国国家卫生研究院;
关键词
Verbal fluency; Twin study; Heritability; Gene-by-environment interaction; Aging; OCCUPATIONAL COMPLEXITY; STRUCTURAL EQUATION; COGNITIVE RESERVE; TWIN; SEX; HERITABILITY; EDUCATION; DEMENTIA; BEHAVIOR; HEALTH;
D O I
10.1007/s10519-021-10048-w
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Despite the relevance of semantic fluency measures to risk for dementia and psychiatric disorders, little is known about their genetic and environmental architecture in mid-to-late life. Participants represent 21,684 middle-aged and older adult twins (M = 60.84 years, SD = 11.21; Range 40-89) from six studies from three countries participating in the Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium. All completed the same measure of semantic fluency (naming animals in 60 seconds). Results revealed small-to-moderate phenotypic associations with age and education, with education more strongly and positively associated with fluency performance in females than males. Heritability and environmental influences did not vary by age. Environmental variance was smaller with higher levels of education, but this effect was observed only in males. This is the largest study to examine the genetic and environmental architecture of semantic fluency, and the first to demonstrate that environmental influences vary based on levels of education.
引用
收藏
页码:99 / 109
页数:11
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