Palladium catalyzed 8-aminoimidazo[1,2-a]pyridine (AIP) directed selective β-C(sp2)-H arylation

被引：9
|
作者：
Mondal, Biswajit [1 ,2 ]
Ghosh, Prasanjit [2 ]
Kundu, MrinalKanti [1 ]
Das, Tapas Kumar [1 ,2 ]
Das, Sajal [2 ]
机构：
[1] TCG Life Sci Pvt Ltd, BN-7,Sect V, Kolkata 700091, India
[2] Univ North Bengal, Dept Chem, Darjeeling 734013, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 02期
关键词：
H BOND ACTIVATION; CYCLIZATION; BIDENTATE; AUXILIARY; DESIGN; DERIVATIVES; SP(2);
D O I：
10.1039/d0ob02134b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium catalyzed arylation of the inert beta-C(sp(2))-H bond of carboxylic acid derivatives is reported herein for the first time utilizing 8-aminoimidazo[1,2-a]pyridine (AIP) as an efficacious and new inbuilt 6,5-fused bicyclic removable directing group. This protocol is scalable, exhibits high levels of beta-site selectivity and tolerates a broad spectrum of functional groups.
引用
收藏
页码：360 / 364
页数：5
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