Plasmodium falciparum Plasmepsin 2 Duplications, West Africa

被引：21
|
作者：
Inoue, Juliana [1 ]
Silva, Miguel [2 ]
Fofana, Bakary [3 ]
Sanogo, Kassim [3 ]
Martensson, Andreas [1 ]
Sagara, Issaka [3 ]
Bjorkman, Anders [4 ]
Veiga, Maria Isabel [2 ]
Ferreira, Pedro Eduardo [2 ]
Djimde, Abdoulaye [3 ]
Gil, Jose Pedro [1 ,4 ,5 ]
机构：
[1] Uppsala Univ, Uppsala, Sweden
[2] Univ Minho, Braga, Portugal
[3] Univ Sci Tech & Technol Bamako, Bamako, Mali
[4] Karolinska Inst, Stockholm, Sweden
[5] Univ Lisbon, Lisbon, Portugal
来源：
EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 08期
基金：
瑞典研究理事会;
关键词：
DIHYDROARTEMISININ-PIPERAQUINE; MALARIA; ASSOCIATION; EFFICACY; MALI;
D O I：
10.3201/eid2408.180370
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.
引用
收藏
页码：1591 / 1593
页数：3
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