Prospects of paramagnetic lanthanide complexes for magnetic resonance imaging, local thermosensing and diagnosing

The features of the paramagnetic properties of lanthanide (Ln) containing complexes with crown ethers, pivaloyltrifluoracetonato, and EDTA have been studied by H-1 and F-19 NMR techniques. These complexes are of interest due to the prospect of using some of them as sensors for biology and medicine. The temperature dependencies of the lanthanide-induced shifts revealed that Ln complexes might have practical importance for H-1 and F-19 NMR temperature control in solutions. It was shown in vitro (using NMR spectrometers and MRI scanners) that these complexes can serve as special NMR thermo-sensitive contrast reagents.