A new method for preparing (2Z, 4Z, 6Z)-diethyl-4,5-oxepinedicarboxylates and some 1H-azepine analogues

被引：2

作者：

Li, Di Zao

Zheng, Zhong Fei

Kang, Zhi Yun

Yu, De Quan ^{[1
]}

机构：

[1] Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2009年 / 20卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Acetylenedicarboxylate; Furans; Pyrroles; Cycloaddition; Oxepine; Azepine;

D O I：

10.1016/j.cclet.2009.02.011

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method for preparing (2Z, 4Z, 6Z)-4,5-diethyloxepinedicarboxylate by one-step is described. The synthesis of several oxepines and azepines derivatives was carried out by the reaction of substituted furans or pyrroles with diethyl acetylenedicarboxylate in boiling toluene. The effect factors for this reaction were discussed and reaction condition was optimized. (C) 2009 Published by Elsevier B.V. on behalf of Chinese Chemical Society.

引用

页码：635 / 639

页数：5

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