Expression of Decorin in Esophageal Cancer in Relation to the Expression of Three Isoforms of Transforming Growth Factor-Beta (TGF-1,-2, and-3) and Matrix Metalloproteinase-2 Activity

被引：18
|
作者：
Augoff, K. [1 ]
Grabowski, K.
Rabczynski, J. [2 ]
Kolondra, A. [3 ]
Tabola, R.
Sikorski, A. F. [3 ]
机构：
[1] Univ Wroclaw, Wroclaw Med Univ, Dept Gastrointestinal & Gen Surg, PL-50369 Wroclaw, Poland
[2] Univ Wroclaw, Dept Pathol Anat, Wroclaw Med Univ, PL-50138 Wroclaw, Poland
[3] Univ Wroclaw, Inst Biochem & Mol Biol, PL-50138 Wroclaw, Poland
来源：
CANCER INVESTIGATION | 2009年 / 27卷 / 04期
关键词：
Decorin; Transforming growth factor-; Metalloproteinase-2; Esophageal cancer; LEUCINE-RICH PROTEOGLYCAN; SQUAMOUS-CELL CARCINOMA; HUMAN COLON-CARCINOMA; EXTRACELLULAR-MATRIX; FACTOR RECEPTOR; BREAST-CANCER; TGF-BETA; COLLAGEN; LUMICAN; GENE;
D O I：
10.1080/07357900802527221
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF- expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the pathological tissues. No obvious alterations in TGF- expression were noticed. The highly significant increase in MMP-2 activity in cancers did not result in elevated levels of TGF- dimers. Therefore, the system of TGF- liberation from its complex with DCN by activated MMP-2 does not seem to contribute to esophageal cancerogenesis, although this hypothesis should be reevaluated with a larger study group.
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页码：443 / 452
页数：10
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