Positive patch test reactions to nickel sulphate are not modified by neighbouring negative fragrance patch tests -: A Multicenter-study by the German Contact Dermatitis Research Group

被引：3
|
作者：
Brasch, Jochen
Weichenthal, Michael
Szliska, Christiane
Loeffler, Harald
Koch, Patrick
Grabbe, Juergen
Mahler, Vera
Kreilgard, Bo
Hoeck, Ulla
机构：
[1] Univ Schlesweg Holstein, Dept Dermatol, D-24105 Kiel, Germany
[2] Krankenhaus Bethesda, Dept Dermatol, Freudenberg, Germany
[3] Univ Marburg, Dept Dermatol, Marburg, Germany
[4] Univ Saarland, Dept Dermatol, D-6650 Homburg, Germany
[5] Univ Schleswig Holstein, Dept Dermatol, Lubeck, Germany
[6] Univ Erlangen Nurnberg, Dept Dermatol, Erlangen, Germany
[7] MEKOS Labs AS, Dept Dermatol, Hillerod, Denmark
来源：
ACTA DERMATO-VENEREOLOGICA | 2006年 / 86卷 / 04期
关键词：
patch test methods; contact sensitivity; diagnosis of contact sensitization;
D O I：
10.2340/00015555-0095
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
It is tacitly assumed that a positive patch test reaction is not affected by adjacent negative tests. However, despite its fundamental importance for the interpretation of test reactions this assumption has not been proven. To test this assumption, special TRUE-test(R) strips were prepared containing placebo, nickel sulphate and fragrance mix as the only allergens, separated by distances of 1 cm and 7 cm and blinded to the investigators. Patients were synchronously tested with two strips. Out of 493 patients tested in 6 centres, the 93 with positive reactions to nickel sulphate only were evaluated. No relevant difference was found between positive nickel reactions in the two different distances to a negative fragrance patch test. We conclude that a positive patch test reaction is not affected by adjacent negative patch tests, which therefore can be neglected for the interpretation of positive reactions.
引用
收藏
页码：345 / 347
页数：3
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