Obesity and Albuminuria Among Adults With Type 2 Diabetes The Look AHEAD (Action for Health in Diabetes) Study

被引：54

作者：

Kramer, Holly ^{[1
,2
]}

Reboussin, David ^{[8
]}

Bertoni, Alain G. ^{[9
]}

Marcovina, Santica ^{[3
]}

Lipkin, Edward ^{[4
]}

Greenway, Frank L., III ^{[7
]}

Brancati, Frederick L. ^{[5
,6
]}

机构：

[1] Loyola Univ, Med Ctr, Dept Med, Div Nephrol & Hypertens, Maywood, IL 60153 USA

[2] Loyola Univ, Med Ctr, Dept Epidemiol & Prevent Med, Div Nephrol & Hypertens, Maywood, IL 60153 USA

[3] NW Lipid Metab & Diabet Res Lab, Dept Med, Seattle, WA USA

[4] Univ Washington & VA Puget Sound Hlth Care Syst, Dept Med, Div Endocrinol & Metab, Seattle, WA USA

[5] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

[6] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA

[7] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA

[8] Wake Forest Univ, Sch Med, Dept Biostat Sci, Winston Salem, NC 27109 USA

[9] Wake Forest Univ, Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC 27109 USA

来源：

DIABETES CARE | 2009年 / 32卷 / 05期

基金：

美国国家卫生研究院;

关键词：

WEIGHT-LOSS; NEPHROPATHY;

D O I：

10.2337/dc08-2059

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - To determine the association between obesity measures and albuminuria in adults with type 2 diabetes. RESEARCH DESIGN AND METHODS - in the Look AHEAD (Action for Health in Diabetes) Study, BMI and waist circumference were measured among 4,985 participants while total percent body fat was measured by whole-body DEXA scans among 1,351 participants. Odds of albuminuria by quartiles of BMI, waist circumference, and percent. total body fat were calculated using logistic regression analysis while adjusting for covariates. RESULTS - The highest quartile of BMI (odds ratio [OR] 1.72 [95% CI 1.40-2.11]) and waist circumference (OR 1.75 [95% CI 1.42-2.15]) was significantly associated with albuminuria compared with the lowest quartile after adjustment for covariates. No associations were noted between quartiles of percent total body fat and albuminuria in an), model. CONCLUSIONS - Increased BMI and abdominal obesity are associated with albuminuria in overweight and obese adults with type 2 diabetes,

引用

页码：851 / 853

页数：3

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