Immune Response Resetting as a Novel Strategy to Overcome SARS-CoV-2-Induced Cytokine Storm

被引:12
|
作者
Nowill, Alexandre E. [1 ]
de Campos-Lima, Pedro O. [2 ,3 ]
机构
[1] Univ Estadual Campinas, Integrated Ctr Pediat OncoHaematol Res, BR-13083210 Campinas, SP, Brazil
[2] Boldrini Childrens Ctr, 1270 Gabriel Porto St, BR-13083210 Campinas, SP, Brazil
[3] Univ Estadual Campinas, Inst Biol, Funct & Mol Biol Grad Program, BR-13083865 Campinas, SP, Brazil
来源
JOURNAL OF IMMUNOLOGY | 2020年 / 205卷 / 10期
关键词
INTERLEUKIN-1 RECEPTOR ANTAGONIST; REACTIVE LYMPH-NODES; SEVERE SEPSIS; SEPTIC SHOCK; BCG VACCINATION; DOUBLE-BLIND; PHASE-III; CELLS; THERAPY; EFFICACY;
D O I
10.4049/jimmunol.2000892
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which rapidly became a pandemic of global proportions. Sepsis is commonly present with high lethality in the severe forms of the disease. The virus-induced cytokine storm puts the immune system in overdrive at the expense of the pathogen-specific immune response and is likely to underlie the most advanced COVID-19 clinical features, including sepsis-related multiple organ dysfunction as well as the pathophysiological changes found in the lungs. We review the major therapeutic strategies that have been considered for sepsis and might be amenable to repurposing for COVID-19. We also discuss two different immunization strategies that have the potential to confer antiviral heterologous protection: innate-induced trained immunity and adaptive-induced immune response resetting.
引用
收藏
页码:2566 / 2575
页数:10
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