Cinchona alkaloid-based chiral catalysts act as highly efficient multifunctional organocatalysts for the asymmetric conjugate addition of malonates to nitroolefins

被引：23

作者：

Ashokkumar, Veeramanoharan ^{[1
]}

Siva, Ayyanar ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Inorgan Chem, Madurai 625021, Tamil Nadu, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 40期

关键词：

ENANTIOSELECTIVE MICHAEL ADDITION; 1,3-DICARBONYL COMPOUNDS; AMINO-ACIDS; DERIVATIVES; MALONONITRILE; CHALCONES; NITROALKENES; ALKYLATION; MECHANISM; KETONES;

D O I：

10.1039/c5ob01351h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New pentaerythritol tetrabromide-based chiral quaternary ammonium salts acting as organocatalysts (7a and 7b) have been prepared and used as organocatalysts for enantioselective Michael addition reactions between various nitroolefins and Michael donors (malonates) under mild reaction conditions, such as lower concentration of base and catalyst and room temperature, with very good chemical yields (up to 97%) and ee's (up to 99%).

引用

页码：10216 / 10225

页数：10

共 43 条

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[43] Chiral bidentate bis(N-heterocyclic carbene)-based palladium complexes bearing carboxylate ligands: Highly effective catalysts for the enantioselective conjugate addition of arylboronic acids to cyclic enones
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