Increased urine phenylethylamine after methylphenidate treatment in children with ADHD

被引：30

作者：

Kusaga, A

Yamashita, Y

Koeda, T

Hiratani, M

Kaneko, M

Yamada, S

Matsuishi, T ^{[1
]}

机构：

[1] Kurume Univ, Sch Med, Dept Pediat & Child Hlth, Kurume, Fukuoka 830, Japan

[2] Tottori Univ, Fac Educ & Reg Sci, Tottori 680, Japan

[3] Hiratani Clin Dev Disorders Children, Fukui, Japan

[4] Saga Med Sch, Dept Psychiat, Saga, Japan

来源：

ANNALS OF NEUROLOGY | 2002年 / 52卷 / 03期

关键词：

D O I：

10.1002/ana.10302

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The urine levels of beta-phenylethylamine, 3-methoxy-4-hydroxyphenyl glycol, homovanillic acid, and 5-hydroxy-indoleacetic acid were measured to clarify the neurochemical mechanism in attention deficit hyperactivity disorder. beta-Phenylethylamine levels were significantly lower in attention deficit hyperactivity disorder individuals (n = 37) than in controls (n = 21). The 22 children with attention deficit hyperactivity disorder were treated with methylphenidate, and they were further divided into methylphenidate responders (n = 18) and nonresponders (n = 4). beta-Phenylethylamine levels significantly increased after methylphenidate therapy in responders, whereas they did not increase in nonresponders.

引用

页码：371 / 374

页数：4

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