Triple stimulation technique in amyotrophic lateral sclerosis

被引:0
|
作者
Krampfl, K [1 ]
Rollnik, J [1 ]
Dengler, R [1 ]
Bufler, J [1 ]
机构
[1] Med Hochschule, Neurol Klin, D-30625 Hannover, Germany
关键词
transcranial magnetic stimulation; amyotrophic lateral sclerosis; triple stimulation technique;
D O I
10.1055/s-2003-814970
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: The authors studied amyotrophic lateral sclerosis (ALS) patients using triple stimulation technique (TST) to detect upper motor neuron (UMN) involvement. Methods: 19 ALS patients (aged 45 - 72 years) were enrolled in the study. According to the El Escorial criteria, 6 diagnoses were suspected or possible, 6 probable, and 7 definite. Patients were examined clinically, using conventional (single-pulse) transcranial magnetic stimulation (TMS), and with TST (on one side only). Results: Among the whole group of patients, TST appeared to be more sensitive than conventional TMS techniques. In particular, among suspected/possible ALS patients, TST area ratio was pathologic in 100%, while single-pulse TMS was abnormal only in 50% of cases. On the whole, the use of TST area ratio was more sensitive than the analysis of TST amplitude ratio. Conclusion: The results suggest that TST might be more sensitive and useful in the diagnosis of subclinical UMN involvement than conventional TMS techniques, even if TST is performed on one side only.
引用
收藏
页码:85 / 89
页数:5
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