Radical-mediated synthesis of trifluoroethyl amines and trifluoromethyl ketones from alkyl iodides

被引：32

作者：

Kim, S ^{[1
]}

Kavali, R

机构：

[1] Korea Adv Inst Sci & Technol, Sch Mol Sci, Ctr Mol Design & Synth, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Sch Mol Sci, Dept Chem, Taejon 305701, South Korea

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 40期

关键词：

radicals and radical reactions; fluorine and compounds; acylation; ketones; amines; sulfones; oximes;

D O I：

10.1016/S0040-4039(02)01675-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Radical reaction of alkyl iodides with trifluoromethyl phenylsulfonyl oxime ether 10 and hexamethylditin at 300 nm in benzene afforded the corresponding trifluoromethyl oxime ethers 11 in high yields, which were reduced into the 2,2,2-trifluoroethyl amines with lithium aluminium hydride. The trifluoroethyl amines could be converted into the corresponding trifluoromethyl ketones by treatment with NBS and DBU. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7189 / 7191

页数：3

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