Synthesis and reactions of some 3-aryl-2-thioxoquinazolin-4(3H)-ones

A series of 3-aryl-2-thioxoquinazolin-4(3H)-ones 1a-g are prepared in good yields from reactions of anthranilic acids, aromatic amines and carbon disulfide under basic conditions in one step. Reaction of aminophenyl derivatives 1a,b with D-glucose affords the corresponding N-glucosylamines 4a,b in very good yields. Diazotization of 1a,b followed by reactions with aromatic amines yield the corresponding azo dyes 6a-f in 40-56% yields. The fastness for 6 has been studied. Compounds 6a,b,f have been proved to biologically active.