Cation-π interactions in ligand recognition and catalysis

被引：399
|
作者：
Zacharias, N [1 ]
Dougherty, DA [1 ]
机构：
[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 06期
关键词：
D O I：
10.1016/S0165-6147(02)02027-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The cation-pi interaction is a potent, general noncovalent binding force that is observed in a wide range of biological contexts. Here, we present an overview of well documented cases in which a cation-pi interaction makes an important contribution to small-molecule recognition at a protein binding site. From these and other studies it is clear that, in addition to the hydrophobic effect, hydrogen bonding and ion pairing, the cation-it interaction must be considered when evaluating drug-receptor interactions.
引用
收藏
页码：281 / 287
页数：7
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