Total synthesis of naamine C and pyronaamidine, antitumor marine imidazole alkaloids

被引:19
|
作者
Nakamura, S [1 ]
Kawasaki, I [1 ]
Kunimura, M [1 ]
Matsui, M [1 ]
Noma, Y [1 ]
Yamashita, M [1 ]
Ohta, S [1 ]
机构
[1] Kyoto Pharmaceut Univ, Misasagi Yamashina Ku, Kyoto 6078414, Japan
关键词
D O I
10.1039/b200845a
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The first total synthesis of naamine C and pyronaamidine, highly substituted and cytotoxic imidazole marine alkaloids of a certain kind of sponge, was achieved through an eight-step reaction starting from 1-methyl-2-phenylthio-1H-imidazole.
引用
收藏
页码:1061 / 1066
页数:6
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