The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol diet

被引：46
|
作者：
Negis, Yesim
Aytan, Nurgul
Ozer, Nesrin
Ogru, Esra
Libinaki, Roksan
Gianello, Robert
Azzi, Angelo
Zingg, Jean-Marc
机构：
[1] Univ Bern, Inst Biochem & Mol Biol, Bern, Switzerland
[2] Marmara Univ, Fac Med, Dept Biochem, TR-81326 Istanbul, Turkey
[3] Phosphagen Ltd, Melbourne, Vic, Australia
[4] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2006年 / 450卷 / 01期
关键词：
tocopherol; antioxidants; atherosclerosis; tocopheryl phosphate;
D O I：
10.1016/j.abb.2006.02.027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of tocopheryl phosphate on atherosclerosis progression has been studied in rabbits, fed with a 2% cholesterol diet and compared with an equivalent amount of alpha-tocopheryl acetate. The results show that the atherosclerotic-preventing effect of the phosphate derivative was more pronounced than that of the acetate derivative. alpha-Tocopheryl phosphate was also more potent in diminishing the expression of CD36 than the acetate derivative. (c) 2006 Elsevier Inc. All rights reserved.
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页码：63 / 66
页数：4
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