Objectives: Early implant failure and donor-site complication remain a concern in patients with thoracolumbar burst fracture underwent one-above and-below short-segment posterior pedicle screw fixation with fusion. Our aim was to evaluate the results of short-segment pedicle instrumentation enforced by two augmenting screws or injectable artificial bone cement in the fractured vertebra, and compare the differences between these two Patients and methods: We conducted a retrospective clinical and radiographic study. Twenty-seven patients were treated with a six-screw construct (group 1), and twenty-nine patients underwenta four-screw construct and fractured vertebra augmentation by injectable calcium sulfate/phosphate cement (group 2). Posterior or posterolateral fusions were not performed in both groups. The severity of the fractured vertebra was evaluated by the load-sharing classification (LSC). Local kyphosis and anterior body height of the fractured vertebra were measured and were follow-up at least 2 years. Any implant failure or loss of correction >10 degrees degrees at the final was defined as failure of surgery. Patients' clinical results were assessed by the Denis scale. Results: Blood loss and operation time were less in group 1 (126.2 +/- 9.7 vs. 267.6 +/- 126.1 ml, p < 0.001 and 141.2 +/- 48.7 vs. 189.8 +/- 16.4 min, p < 0.001). Immediately after surgery, group 2 had a better local kyphosis angle (3.7 +/- 5.3 vs.6.0 +/- 4.1 degrees, p = 0.047) and acquired more anterior body height (94.9% +/- 7.6% vs. 84.9% +/- 10.0%, p < 0.001). Both groups had similar clinical results (pain score: 1.5 +/- 0.8vs. 1.4 +/- 0.6, p = 0.706; work score: 1.7 +/- 0.9 vs. 1.6 +/- 1.0, p = 0.854). Group 1 had 3 cases of surgery failure; group 2 had 8 cases of implant failure (p = 0.121). The average LSC score of these 11 patients with surgical failure was 7.2. Conclusion: Thesix-screw construct had the advantage of shorter operating time, less blood loss, and lower failure rate. For those patients with anLSC score >= 7, posterior short-segment instrumentation should be used cautiously. (C) 2016 Elsevier B.V. All rights reserved.