Large-Scale Identification and Analysis of Suppressive Drug Interactions

被引：22

作者：

Coko, Murat ^{[1
,2
]}

Weinstein, Zohar B. ^{[1
,3
]}

Yilancioglu, Kaan ^{[1
,3
]}

Tasan, Murat ^{[3
]}

Doak, Allison ^{[4
]}

Cansever, Dilay ^{[1
,3
]}

Mutlu, Beste ^{[1
,3
]}

Li, Siyang ^{[3
]}

Rodriguez-Esteban, Raul ^{[5
]}

Akhmedov, Murodzhon ^{[1
]}

Guvenek, Aysegul ^{[1
]}

Cokol, Melike ^{[1
]}

Cetiner, Selim ^{[1
]}

Giaever, Guri ^{[3
,6
]}

Iossifov, Ivan ^{[7
]}

Nislow, Corey ^{[3
,6
]}

Shoichet, Brian ^{[4
]}

Roth, Frederick P. ^{[3
,8
,9
,10
,11
]}

机构：

[1] Sabanci Univ, Biol Sci & Bioengn Program, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey

[2] Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey

[3] Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada

[4] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA

[5] Boehringer Ingelheim Pharmaceut Inc, Dept Computat Biol, Ridgefield, CT 06877 USA

[6] Univ British Columbia, Dept Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada

[7] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[8] Dana Farber Canc Inst, Ctr Canc Syst Biol, Boston, MA 02215 USA

[9] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada

[10] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada

[11] Univ Toronto, Dept Comp Sci, Toronto, ON M5S 3E1, Canada

来源：

CHEMISTRY & BIOLOGY | 2014年 / 21卷 / 04期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ANALYSIS; SACCHAROMYCES-CEREVISIAE; ANTIBIOTIC-RESISTANCE; CANCER-THERAPY; MUTANTS; YEAST; 3-BROMOPYRUVATE; INHIBITION; PATHWAYS; TARGETS;

D O I：

10.1016/j.chembiol.2014.02.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One drug may suppress the effects of another. Although knowledge of drug suppression is vital to avoid efficacy-reducing drug interactions or discover countermeasures for chemical toxins, drug-drug suppression relationships have not been systematically mapped. Here, we analyze the growth response of Saccharomyces cerevisiae to anti-fungal compound ("drug") pairs. Among 440 ordered drub pairs, we identified 94 suppressive drug interactions. Using only pairs not selected on the basis of their suppression behavior, we provide an estimate of the prevalence of suppressive interactions between anti-fungal compounds as 17%. Analysis of the drug suppression network suggested that Bromopyruvate is a frequently suppressive drug and Staurosporine is a frequently suppressed drug. We investigated potential explanations for suppressive drug interactions, including chemogenomic analysis, coaggregation, and pH effects, allowing us to explain the interaction tendencies of Bromopyruvate.

引用

页码：541 / 551

页数：11

共 50 条

[21] Predicting Drug-Drug Interactions Through Large-Scale Similarity-Based Link Prediction
Fokoue, Achille
Sadoghi, Mohammad
Hassanzadeh, Oktie
Zhang, Ping
SEMANTIC WEB: LATEST ADVANCES AND NEW DOMAINS, 2016, 9678 : 774 - 789
[22] Towards reproducibility in large-scale analysis of protein-protein interactions
Lund-Johansen, Fridtjof
Tran, Trung
Mehta, Adi
NATURE METHODS, 2021, 18 (07) : 720 - 721
[23] A scalable framework for large-scale analysis of gene-gene interactions
Hmidal, Moez Ben Haj
Slimani, Yahya
2014 IEEE INTERNATIONAL CONFERENCE ON CLUSTER COMPUTING (CLUSTER), 2014, : 380 - 384
[24] From large-scale assays to mechanistic insights: computational analysis of interactions
Jaimovich, Ariel
Friedman, Nir
CURRENT OPINION IN BIOTECHNOLOGY, 2011, 22 (01) : 87 - 93
[25] MONITORING LARGE-SCALE CRYOSPHERE ATMOSPHERE INTERACTIONS
ROPELEWSKI, CF
REMOTE SENSING OF ATMOSPHERE AND OCEANS, 1989, 9 : 213 - 218
[26] Intraguild interactions and large-scale population patterns
Sircom, Julie
Walde, Sandra J.
JOURNAL OF THE NORTH AMERICAN BENTHOLOGICAL SOCIETY, 2009, 28 (03): : 649 - 658
[27] Large-scale analysis of the yeast proteome by multidimensional protein identification technology
Michael P. Washburn
Dirk Wolters
John R. Yates
Nature Biotechnology, 2001, 19 : 242 - 247
[28] Large-scale analysis of the yeast proteome by multidimensional protein identification technology
Washburn, MP
Wolters, D
Yates, JR
NATURE BIOTECHNOLOGY, 2001, 19 (03) : 242 - 247
[29] Introduction and Analysis of a Large-Scale Benchmark Automatic Vehicle Identification Dataset
He, Zhaocheng
Chen, Kaiying
Chen, Xinyu
Sun, Weiwei
INTERNATIONAL CONFERENCE ON TRANSPORTATION AND DEVELOPMENT 2018: CONNECTED AND AUTONOMOUS VEHICLES AND TRANSPORTATION SAFETY, 2018, : 35 - 43
[30] Spectral fingerprints of large-scale neuronal interactions
Siegel, Markus
Donner, Tobias H.
Engel, Andreas K.
NATURE REVIEWS NEUROSCIENCE, 2012, 13 (02) : 121 - 134

← 1 2 3 4 5 →