Life-threatening autoimmune warm hemolytic anemia following treatment for multiple sclerosis with alemtuzumab

被引：14
|
作者：
Meunier, Benoit [2 ]
Rico, Audrey [1 ]
Seguier, Julie [2 ]
Boutiere, Clemence [1 ]
Ebbo, Mikael [2 ]
Harle, Jean Robert [2 ]
Schleinitz, Nicolas [2 ]
Pelletier, Jean [1 ]
机构：
[1] Hop La Timone, AP HM, Pole Neurosci Clin, Serv Neurol, F-13385 Marseille, France
[2] Hop La Timone, AP HM, Dept Med Interne, Marseille, France
来源：
MULTIPLE SCLEROSIS JOURNAL | 2018年 / 24卷 / 06期
关键词：
Multiple sclerosis; alemtuzumab; hemolytic anemia; CONTROLLED PHASE-3 TRIAL;
D O I：
10.1177/1352458517729766
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Alemtuzumab is a humanized monoclonal antibody directed at CD52 approved as a disease-modifying therapy for relapsing forms of multiple sclerosis (MS). Objective: To describe a case of a life-threatening autoimmune anemia occurring after a first course of alemtuzumab for relapsing-remitting MS in a 28-year-old male. Methods: Case report. Results: A 28-year-old male developed a life-threatening autoimmune anemia occurring 11months after first alemtuzumab course. Conclusion: We report the third case of autoimmune hemolytic anemia following treatment with alemtuzumab in a young MS patient. Due to the severity of this adverse event, neurologists using this treatment should be alert.
引用
收藏
页码：811 / 813
页数：3
相关论文
共 50 条
  • [41] Thyroid storm and warm autoimmune hemolytic anemia
    Moore, Joseph A.
    Gliga, Louise
    Nagalla, Srikanth
    TRANSFUSION AND APHERESIS SCIENCE, 2017, 56 (04) : 606 - 608
  • [42] Updates in the Management of Warm Autoimmune Hemolytic Anemia
    Yui, Jennifer C.
    Brodsky, Robert A.
    HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2022, 36 (02) : 325 - 339
  • [43] Educational Case: Warm Autoimmune Hemolytic Anemia
    Arays, Ruta
    Shmookler, Aaron D.
    ACADEMIC PATHOLOGY, 2020, 7
  • [44] Daratumumab for refractory warm autoimmune hemolytic anemia
    Jain, Ankur
    Gupta, D. K.
    ANNALS OF HEMATOLOGY, 2021, 100 (05) : 1351 - 1353
  • [45] Immunotherapy Treatments of Warm Autoimmune Hemolytic Anemia
    Liu, Bainan
    Gu, Wangang
    CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2013,
  • [46] Daratumumab for refractory warm autoimmune hemolytic anemia
    Ankur Jain
    D. K. Gupta
    Annals of Hematology, 2021, 100 : 1351 - 1353
  • [47] Sirolimus for treatment of refractory primary warm autoimmune hemolytic anemia in children
    Williams, Olatundun
    Bhat, Rukhmi
    Badawy, Sherif M.
    BLOOD CELLS MOLECULES AND DISEASES, 2020, 83
  • [48] Warm Autoimmune Hemolytic Anemia: Recent Progress in Understanding the Immunobiology and the Treatment
    Barros, Melca M. O.
    Blajchman, Morris A.
    Bordin, Jose O.
    TRANSFUSION MEDICINE REVIEWS, 2010, 24 (03) : 195 - 210
  • [49] COMPREHENSIVE CARE FOLLOWING MULTIPLE, LIFE-THREATENING INJURIES - TREATMENT OF AN ADOLESCENT BOY
    KOHLBERG, IJ
    ROTHENBERG, MB
    AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1970, 119 (05): : 449 - +
  • [50] HEMOLYTIC WARM IGM AUTOAGGLUTININS IN AUTOIMMUNE HEMOLYTIC-ANEMIA
    FREEDMAN, J
    WRIGHT, J
    LIM, FC
    GARVEY, MB
    TRANSFUSION, 1987, 27 (06) : 464 - 467
12345