Life-threatening autoimmune warm hemolytic anemia following treatment for multiple sclerosis with alemtuzumab

被引：14
|
作者：
Meunier, Benoit [2 ]
Rico, Audrey [1 ]
Seguier, Julie [2 ]
Boutiere, Clemence [1 ]
Ebbo, Mikael [2 ]
Harle, Jean Robert [2 ]
Schleinitz, Nicolas [2 ]
Pelletier, Jean [1 ]
机构：
[1] Hop La Timone, AP HM, Pole Neurosci Clin, Serv Neurol, F-13385 Marseille, France
[2] Hop La Timone, AP HM, Dept Med Interne, Marseille, France
来源：
MULTIPLE SCLEROSIS JOURNAL | 2018年 / 24卷 / 06期
关键词：
Multiple sclerosis; alemtuzumab; hemolytic anemia; CONTROLLED PHASE-3 TRIAL;
D O I：
10.1177/1352458517729766
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Alemtuzumab is a humanized monoclonal antibody directed at CD52 approved as a disease-modifying therapy for relapsing forms of multiple sclerosis (MS). Objective: To describe a case of a life-threatening autoimmune anemia occurring after a first course of alemtuzumab for relapsing-remitting MS in a 28-year-old male. Methods: Case report. Results: A 28-year-old male developed a life-threatening autoimmune anemia occurring 11months after first alemtuzumab course. Conclusion: We report the third case of autoimmune hemolytic anemia following treatment with alemtuzumab in a young MS patient. Due to the severity of this adverse event, neurologists using this treatment should be alert.
引用
收藏
页码：811 / 813
页数：3
相关论文
共 50 条
  • [1] Splenic artery embolization for the management of severe life-threatening warm autoimmune hemolytic anemia
    Egbaria, Aya
    Bisharat, Naiel
    HEMATOLOGY, 2025, 30 (01)
  • [2] Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation
    Schuetz, Catharina
    Hoenig, Manfred
    Moshous, Despina
    Weinstock, Christof
    Castelle, Martin
    Bendavid, Matthieu
    Shimano, Kristin
    Tolbert, Vanessa
    Schulz, Ansgar S.
    Dvorak, Christopher C.
    BLOOD ADVANCES, 2018, 2 (19) : 2550 - 2553
  • [3] Efficacy of eculizumab in refractory life-threatening warm autoimmune hemolytic anemia associated with chronic myelomonocytic leukemia
    Gauchy, Anne-Cecile
    Hentzien, Maxime
    Wynckel, Alain
    de Marcellus, Victoire
    Rodier, Cyrielle
    Delmer, Alain
    Quinquenel, Anne
    CLINICAL CASE REPORTS, 2020, 8 (12): : 2641 - 2644
  • [4] Concurrent autoimmune hemolytic anemia and multiple sclerosis relapse in the presence of aquaporin-1 antibodies, following treatment with Alemtuzumab
    Tzartos, J.
    Tzanetakos, D.
    Valsami, S.
    Stergiou, C.
    Barbarousi, D.
    Psimenou, E.
    Kilintireas, K.
    MULTIPLE SCLEROSIS JOURNAL, 2019, 25 : 867 - 867
  • [5] Warm autoimmune hemolytic anemia following pancreas transplantation and immunosuppression with alemtuzumab, mycophenolate, and daclizumab
    Elimelakh, M.
    Key, N.
    Gruessner, R.
    Sutherland, D.
    Gruessner, A.
    Bland, B.
    Eubank, J.
    Ward, N.
    Eastlund, T.
    TRANSFUSION, 2006, 46 (09) : 129A - 129A
  • [6] Sirolimus as Maintenance Treatment in an Infant With Life-threatening Multiresistant Pure Red Cell Anemia/Autoimmune Hemolytic Anemia
    Miano, Maurizio
    Poggi, Vincenzo
    Banov, Laura
    Fioredda, Francesca
    Micalizzi, Concetta
    Svahn, Johanna
    Montobbio, Giovanni
    Gallicola, Federica
    Molinari, Angelo C.
    Parasole, Rosanna
    Petruzziello, Fara
    Fischer, Alain
    Calvillo, Michaela
    Dufour, Carlo
    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2014, 36 (03) : E145 - E148
  • [7] Severe autoimmune intravascular hemolytic anemia in patients receiving alemtuzumab for multiple sclerosis
    Sharma, Parth
    Saksena, Annapurna
    Diaz, Adolfo
    Pang, Yifan
    Desai, Parth
    BLOOD ADVANCES, 2023, 7 (11) : 2534 - 2537
  • [8] Life-Threatening Severe Thrombocytopenia and Mild Autoimmune Hemolytic Anemia Associated with Brucellosis
    Ahmed, Waleed Amsaib M.
    Ahmed Khalil, Khalid
    Azwari, Asma
    Ebid, Gamal T. A.
    Nazir, Imran
    Aly, Mohamed Hassan
    CASE REPORTS IN INFECTIOUS DISEASES, 2023, 2023
  • [9] ANCA-associated life-threatening systemic vasculitis after alemtuzumab treatment for multiple sclerosis
    Horisberger, Alice
    Pantazou, Vasiliki
    Cuendet, Geraldine
    Ribi, Camillo
    Dunet, Vincent
    Theaudin, Marie
    MULTIPLE SCLEROSIS JOURNAL, 2020, 26 (12) : 1599 - 1602
  • [10] Autoimmune encephalitis following alemtuzumab treatment of multiple sclerosis
    Giarola, Blake
    Massey, Jennifer
    Barnett, Yael
    Rodrigues, Michael
    Sutton, Ian
    MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2019, 28 : 31 - 33
12345