No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

被引：8
|
作者：
Phillips, Lynette S.
Thompson, Cheryl L. [2 ]
Merkulova, Alona [3 ]
Plummer, Sarah J. [4 ]
Tucker, Thomas C. [5 ]
Casey, Graham [4 ]
Li, Li [1 ,2 ]
机构：
[1] Case Western Reserve Univ, Div Res, Dept Family Med,Case Comprehens Canc Ctr, Case Ctr Transdisciplinary Res Energet & Canc, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Epidemiol & Biostat, Case Comprehens Canc Ctr, Case Ctr Transdisciplinary Res Energet & Canc, Cleveland, OH 44106 USA
[3] Cleveland Clin Fdn, Dept Canc Biol, Cleveland, OH 44195 USA
[4] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90033 USA
[5] Univ Kentucky, Markey Canc Ctr, Lexington, KY 40504 USA
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2009年 / 15卷 / 30期
关键词：
Colon cancer; Phosphatase and tensin homolog; Candidate gene; Genetic polymorphisms; Single nucleotide polymorphism association; PHOSPHOINOSITIDE 3-KINASE/AKT PATHWAY; COLORECTAL-CANCER; SIGNALING PATHWAY; TUMOR-SUPPRESSOR; PROSTATE-CANCER; PTEN MUTATIONS; COWDEN DISEASE; EXPRESSION; BREAST; POPULATION;
D O I：
10.3748/wjg.15.3771
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged >= 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. (C) 2009 The WJG Press and Baishideng. All rights reserved.
引用
收藏
页码：3771 / 3775
页数：5
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