Enantioselective O-allylic alkylation of Morita-Baylis-Hillman carbonates with oxime

被引：19
|
作者：
Hu ZeKai [1 ]
Cui HaiLei [1 ]
Jiang Kun [1 ]
Chen YingChun [1 ]
机构：
[1] Sichuan Univ, W China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist,Dept Med Chem, Chengdu 610041, Peoples R China
来源：
SCIENCE IN CHINA SERIES B-CHEMISTRY | 2009年 / 52卷 / 09期
基金：
中国国家自然科学基金;
关键词：
asymmetric organocatalysis; allylic alkylation; oxime; Morita-Baylis-Hillman carbonates; ALPHA; BETA-UNSATURATED ALDEHYDES; BETA-HYDROXYLATION; SUBSTITUTION; RESOLUTION; ALCOHOLS; ACETATES; ADDUCTS;
D O I：
10.1007/s11426-009-0187-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The enantioselective O-allylic alkylation of acetophenone oxime with various Morita-Baylis-Hillman (MBH) carbonates has been accomplished by the catalysis of a commercially available cinchona alkaloid (DHQD)(2)PHAL. The corresponding O-allylic products were obtained in moderate to excellent yields up to 96% ee.
引用
收藏
页码：1309 / 1313
页数：5
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