Why and how have drug discovery strategies in pharma changed? What are the new mindsets?

被引：53

作者：

Mignani, Serge ^{[1
]}

Huber, Scot ^{[2
]}

Tomas, Helena

Rodrigues, Joao ^{[3
]}

Majoral, Jean-Pierre ^{[4
,5
]}

机构：

[1] Univ Paris 05, CNRS UMR 860, Lab Chim & Biochim Pharmacol & Toxicol, PRES Sorbonne Paris Cite, 45 Rue St Peres, F-75006 Paris, France

[2] SCYNEXIS Inc, POB 12878, Res Triangle Pk, NC 27709 USA

[3] Univ Madeira, CQM, MMRG, Campus Univ Penteada, P-9000390 Funchal, Portugal

[4] CNRS, Lab Chim Coordinat, 205 Route Narbonne,BP 44099, F-31077 Toulouse 4, France

[5] Univ Toulouse, UPS, INPT, F-31077 Toulouse 4, France

来源：

DRUG DISCOVERY TODAY | 2016年 / 21卷 / 02期

关键词：

CHEMICAL BEAUTY; OPEN INNOVATION; 1ST-IN-CLASS; CHALLENGES; REVOLUTION; IMPACT; SPACE;

D O I：

10.1016/j.drudis.2015.09.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the pharmaceutical industry the long-term challenge of drug innovation is the key phrase throughout R&D that refers to increasing the output of original drug candidate molecules. To increase R&D productivity, implementation of new and strategic R&D orientations to develop new approaches or systems to identify hits and leads efficiently has taken place and enabled all scientists working in the drug discovery domain to develop innovative medicines for the 21st century.

引用

页码：239 / 249

页数：11

共 50 条

[41] A REVIEW ON POLYMER DRUG CONJUGATE - WHAT, WHY AND HOW?
Patil, J. P.
Mahajan, H. S.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2015, 6 (11): : 4611 - 4621
[42] New social media nones: how and why Americans have changed their use of social media to consume political news
Morris, David S. S.
Morris, Jonathan S. S.
JOURNAL OF INFORMATION COMMUNICATION & ETHICS IN SOCIETY, 2023, 21 (04): : 468 - 484
[43] How academic labs can approach the drug discovery process as a way to synergize with big pharma
Loregian, Arianna
Palu, Giorgio
TRENDS IN MICROBIOLOGY, 2013, 21 (06) : 261 - 264
[44] FDA, NIH, pharma companies seek new strategies to spur drug development
Wechsler, Jill
FORMULARY, 2011, 46 (05) : 196 - 197
[45] The Fiftieth year of Economic Analysis and Policy: How, why, and to what extent has it changed?
Tisdell, Clement A.
ECONOMIC ANALYSIS AND POLICY, 2020, 68 : A1 - A9
[46] What inventory behavior tells us about how business cycles have changed
Sarte, Pierre-Daniel
Schwartzman, Felipe
Lubik, Thomas A.
JOURNAL OF MONETARY ECONOMICS, 2015, 76 : 264 - 283
[47] The new world of global drug development: What pharma managers need to know
Stober M.
International Journal of Pharmaceutical Medicine, 2004, 18 (2) : 69 - 79
[48] The Who, What, Where, When, Why, and How of Drug Desensitization
Yang, Barbara C.
Castells, Mariana C.
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2022, 42 (02) : 403 - 420
[49] New Strategies for Carbohydrate-Based Drug Discovery
Wong, Chi-Huey
FASEB JOURNAL, 2008, 22
[50] New Modalities and Strategies in Drug Delivery and Discovery Foreword
Ishida, Tatsuhiro
Kogure, Kentaro
Tachikawa, Masanori
Baba, Kazuhiko
CHEMICAL & PHARMACEUTICAL BULLETIN, 2022, 70 (05) : 309 - 309

← 1 2 3 4 5 →