Construction of N-C Axial Chirality through Atroposelective C-H Olefination of N-Arylindoles by Palladium/Amino Acid Cooperative Catalysis

被引：31

作者：

Zhang, Jitan ^{[1
]}

Xu, Qiaoqiao ^{[1
]}

Wu, Jiaping ^{[1
]}

Fan, Jian ^{[1
]}

Xie, Meihua ^{[1
]}

机构：

[1] Anhui Normal Univ, Coll Chem & Mat Sci, Anhui Key Lab Mol Based Mat, Key Lab Funct Mol Solids,Minist Educ, Wuhu 241002, Anhui, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 16期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; BIARYL ATROPISOMERS; KINETIC RESOLUTION; LIGANDS; FUNCTIONALIZATION; ALKYLATION; ACTIVATION; MEBROQUALONE; DERIVATIVES;

D O I：

10.1021/acs.orglett.9b02243

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct construction of N-C axial chirality via Pd-catalyzed atroposelective C-H olefination of N-arylindoles is reported. The crucial role of chiral amino acid as a cocatalyst in the regio- and stereocontrol has been disclosed. In this reaction, a wide range of arylindoles and functional alkenes could be well tolerated. Moreover, the practicality and synthetic value of this process were demonstrated by the divers and simple transformations of the products.

引用

页码：6361 / 6365

页数：5

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