Cast epoxy-based microfluidic systems and their application in biotechnology

This paper reports the development of epoxy microcasting technologies for the fabrication of plastic microfluidic platforms. Two new techniques one involving embedding active silicon devices in plastic microsystems using a polymer flip chip process and another involving surface micromachining to build active components like actuators for use in applications like pumping are discussed and explained. Application devices were fabricated for polymerase chain reaction (PCR) and capillary electrophoresis (CE). (C) 2003 Elsevier B.V. All rights reserved.