Enzyme-catalyzed sulfide ring formation in lantibiotics

被引：9
|
作者：
Jung, Guenther [1 ]
机构：
[1] Univ Tubingen, Inst Organ Chem, D-72075 Tubingen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 36期
关键词：
biosynthesis; cyclization; enzyme catalysis; metalloenzymes; zinc;
D O I：
10.1002/anie.200601850
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Building bridges: The crystal structure of the zinc enzyme NisC was solved recently by X-ray diffraction. This cyclase single-handedly catalyzes the formation of several sulfide bridges in the dehydrated precursor protein NisA of the lantibiotic nisin. The Highlight discusses the impact of these results on the field of lantibiotic research. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5919 / 5921
页数：3
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