Efficient reaction pathway for the synthesis of saturated and mono-unsaturated 2-alkylcyclobutanones

被引：11
|
作者：
Miesch, M
Miesch, L
Horvatovich, P
Burnouf, D
Delincée, H
Hartwig, A
Raul, F
Werner, D
Marchioni, E
机构：
[1] Univ Strasbourg 1, Fac Chim, UMR 7123, Lab Chim Organ Synth, F-67000 Strasbourg, France
[2] Univ Strasbourg 1, Fac Pharm, UMR 7512, Lab Chim Analyt & Sci Aliment, F-67000 Strasbourg, France
[3] IRCAD, Lab Prevetn Nutr Canc, INSERM, U 392, F-67000 Strasbourg, France
[4] IRCAD, Grp Epidemiol Mol Canc, CNRS, UPR 9003, F-67000 Strasbourg, France
[5] Bundesforschungsanstalt Ernahrung, D-76131 Karlsruhe, Germany
[6] Univ Karlsruhe, Inst Lebensmittelchem & Toxikol, D-76128 Karlsruhe, Germany
[7] IRCAD, Grp Epidemiol Mol Canc, CNRS, UPR 9003, F-67000 Strasbourg, France
[8] Aerial, F-67300 Schiltigheim, France
来源：
RADIATION PHYSICS AND CHEMISTRY | 2002年 / 65卷 / 03期
关键词：
synthesis; irradiation; 2-alkylcyclobutanones; food;
D O I：
10.1016/S0969-806X(02)00265-7
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A synthetic pathway leading to saturated and mono-unsaturated 2-alkylcyclobutanones has been developed and proved to be very efficient and fast to realize. It was used to produce gram amounts of different 2-alkylcyclobutanones with saturated and mono-unsaturated alkyl side chain (2-decyl-, 2-dodecyl-, 2-dodecenyl-, 2-tetradecyl- and 2-tetradecenyl-cyclobutanone), necessary for in vitro and in vivo biological studies. The excellent chromatographic characteristics (purity better than 97%) of the synthesized compounds made it also possible to use them as chromatographic reference samples for the analysis of irradiated foodstuffs. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：233 / 239
页数：7
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