Efficient reaction pathway for the synthesis of saturated and mono-unsaturated 2-alkylcyclobutanones

被引：11
|
作者：
Miesch, M
Miesch, L
Horvatovich, P
Burnouf, D
Delincée, H
Hartwig, A
Raul, F
Werner, D
Marchioni, E
机构：
[1] Univ Strasbourg 1, Fac Chim, UMR 7123, Lab Chim Organ Synth, F-67000 Strasbourg, France
[2] Univ Strasbourg 1, Fac Pharm, UMR 7512, Lab Chim Analyt & Sci Aliment, F-67000 Strasbourg, France
[3] IRCAD, Lab Prevetn Nutr Canc, INSERM, U 392, F-67000 Strasbourg, France
[4] IRCAD, Grp Epidemiol Mol Canc, CNRS, UPR 9003, F-67000 Strasbourg, France
[5] Bundesforschungsanstalt Ernahrung, D-76131 Karlsruhe, Germany
[6] Univ Karlsruhe, Inst Lebensmittelchem & Toxikol, D-76128 Karlsruhe, Germany
[7] IRCAD, Grp Epidemiol Mol Canc, CNRS, UPR 9003, F-67000 Strasbourg, France
[8] Aerial, F-67300 Schiltigheim, France
来源：
RADIATION PHYSICS AND CHEMISTRY | 2002年 / 65卷 / 03期
关键词：
synthesis; irradiation; 2-alkylcyclobutanones; food;
D O I：
10.1016/S0969-806X(02)00265-7
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A synthetic pathway leading to saturated and mono-unsaturated 2-alkylcyclobutanones has been developed and proved to be very efficient and fast to realize. It was used to produce gram amounts of different 2-alkylcyclobutanones with saturated and mono-unsaturated alkyl side chain (2-decyl-, 2-dodecyl-, 2-dodecenyl-, 2-tetradecyl- and 2-tetradecenyl-cyclobutanone), necessary for in vitro and in vivo biological studies. The excellent chromatographic characteristics (purity better than 97%) of the synthesized compounds made it also possible to use them as chromatographic reference samples for the analysis of irradiated foodstuffs. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：233 / 239
页数：7
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