Correlation of intellectual impairment in Parkinson's disease with FDG PET scan

被引：12
|
作者：
Wu, JC [1 ]
Iacono, R
Ayman, M
Salmon, E
Lin, SD
Carlson, J
Keator, D
Lee, A
Najafi, A
Fallon, J
机构：
[1] Loma Linda Univ, Sch Med, Dept Psychiat & Human Behav, Brain Imaging Ctr, Loma Linda, CA 92350 USA
[2] Univ Calif Irvine, Dept Anat, Irvine, CA 92697 USA
来源：
NEUROREPORT | 2000年 / 11卷 / 10期
关键词：
emission computed tomography; FDG; Parkinson's disease;
D O I：
10.1097/00001756-200007140-00016
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study investigated the relationship between regional glucose metabolism with intellectual impairment in patients with Parkinson's disease using statistical parametric mapping. Regional cerebral glucose metabolism using [F-18]deoxyglucose (FDG) PET scans were performed on 10 patients with Parkinson's disease. We used the intellectual impairment score from the UPDRS. PET scans were analyzed with SPM96. Patients showed significant positive correlations with left limbic structures such as the cingulate gyrus, parahippocampal gyrus, and medial frontal gyrus. Patients showed significant negative correlations with associative neocortical posterior structures such as bilateral parietal and occipital gyrus. There were significant relationships between regional glucose metabolism and intellectual impairment. NeuroReport 11:2139-2144 (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码：2139 / 2144
页数：6
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