WNT Signaling in Disease

被引：190

作者：

Ng, Li Fang ^{[1
]}

Kaur, Prameet ^{[1
]}

Bunnag, Nawat ^{[1
]}

Suresh, Jahnavi ^{[1
]}

Sung, Isabelle Chiao Han ^{[1
]}

Tan, Qian Hui ^{[1
]}

Gruber, Jan ^{[1
]}

Tolwinski, Nicholas S. ^{[1
]}

机构：

[1] Yale NUS Coll, Res Labs E6, Div Sci, E6,5 Engn Dr 1,04-02, Singapore 117608, Singapore

来源：

CELLS | 2019年 / 8卷 / 08期

关键词：

WNT; cancer; metabolic syndrome; Alzheimer's disease; WNT/BETA-CATENIN PATHWAY; RECEPTOR-RELATED PROTEIN-5; SMALL-MOLECULE INHIBITOR; FAMILIAL ADENOMATOUS POLYPOSIS; GLYCOGEN-SYNTHASE KINASE-3; FRAGILE-X-SYNDROME; CANCER STEM-CELLS; BETA-CATENIN; MATRIX METALLOPROTEINASE-7; OXIDATIVE STRESS;

D O I：

10.3390/cells8080826

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans. Here, we discuss the WNT pathway and its role in human disease and some of the advances in WNT-related treatments.

引用

页数：32

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