Determination and correlation of solubility and thermodynamic properties of L-methionine in binary solvents of water plus (methanol, ethanol, acetone)

The solubility of L-methionine in three different binary mixed solvents of water + (methanol, ethanol, acetone) were experimentally measured by gravimetric method from T = (283.15 to 313.15) K (P = 0.1 MPa). The experimental data indicate that the solubility of L-methionine in the binary mixed solvents increases with the increasing temperature and decreases with the rise of molar concentration of organic solvents. The modified Apelblat model, the lambda h model and the CNIBS/R-K model were used to correlate the experimental data, and all of the models provided good fitting to the data. Furthermore, the mixing thermodynamic properties of L-methionine in different binary solvent mixtures were also calculated and discussed. The results indicate that the mixing process of L-methionine in the investigated solvents is endothermic and spontaneous. The experimental solubility and correlation equations can be used as essential data and simulation models in the purification and separation of L-methionine. (C) 2015 Elsevier Ltd. All rights reserved.