Leptin expression in colorectal and breast cancer patients

被引：20

作者：

Tessitore, L

Vizio, B

Jenkins, O

De Stefano, I

Ritossa, C

Argiles, JM

Benedetto, C

Mussa, A

机构：

[1] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci Med, I-13100 Vercelli, Italy

[2] SmithKline Beecham Pharmaceut, Dept Gene Express Sci, Harlow CM19 5AD, Essex, England

[3] Osped S Luigi Gonzaga, Dipartimento Chirurg, I-10043 Turin, Italy

[4] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, E-08071 Barcelona, Spain

[5] Osped S Anna, Dipartimento Ginecol & Ostetr, I-10126 Turin, Italy

[6] Univ Turin, Dipartimento Discipline Medicochirurg, I-10126 Turin, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2000年 / 5卷 / 04期

关键词：

leptin; cancer patient; cachexia; clinical marker; hormones;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Leptin is a hormone which controls fat metabolism. Leptin plasma levels and adipose tissue mRNA expression were measured in cancer patients. Plasma levels were correlated with TNM staging, cachexia parameters, tumour markers and hormones. Breast and colorectal cancer patients showed blood plasma levels of insulin, TNF-alpha and tumour markers higher than controls. Breast cancer patients, but not colorectal cancer patients, had plasma levels and adipose tissue expression of leptin significantly higher than controls associated with elevated values of estrogen- and progesterone-receptors. These data suggest the possible use of leptin as a clinical marker.

引用

页码：421 / 426

页数：6

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