Arene-Ruthenium(II) Complexes with Bioactive ortho-Hydroxydibenzoylmethane Ligands: Synthesis, Structure, and Cytotoxicity

被引：25
|
作者：
Pettinari, Riccardo [1 ]
Petrini, Agnese [1 ]
Marchetti, Fabio [2 ]
Pettinari, Claudio [1 ]
Riedel, Tina [3 ]
Therrien, Bruno [4 ]
Dyson, Paul J. [3 ]
机构：
[1] Univ Camerino, Sch Pharm, Via S Agostino 1, I-62032 Camerino, MC, Italy
[2] Univ Camerino, Sch Sch Sci & Technol, Via S Agostino 1, I-62032 Camerino, MC, Italy
[3] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
[4] Univ Neuchatel, Inst Chim, Ave Bellevaux 51, CH-2000 Neuchatel, Switzerland
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2017年 / 12期
基金：
瑞士国家科学基金会;
关键词：
Ruthenium; Arene ligands; Biological activity; Metal-based drugs; Cytotoxicity; Cancer; RUTHENIUM(II) ARENE COMPLEXES; ANTICANCER COMPLEXES; ANTITUMOR-ACTIVITY; DNA-ADDUCTS; IN-VITRO; X-RAY; DIBENZOYLMETHANE; APOPTOSIS; CURCUMIN; COORDINATION;
D O I：
10.1002/ejic.201601164
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis of a series of neutral arene-ruthenium (II) complexes (arene = p-cymene, hexamethylbenzene, and benzene) [(arene)Ru(HDB) Cl] derived from the reaction of the appropriate arene-ruthenium(II) dimers and ortho-hydroxydibenzoylmethane (HDBH), a potent inhibitor of cell proliferation, is described. In addition, related ionic complexes [(arene)Ru(HDB)(PTA)](SO3CF3) (PTA = 1,3,5-triaza-7-phosphaadamantane) have been prepared. The structure of three complexes has been confirmed by X-ray crystallography. The cytotoxicity of the complexes has been evaluated against human ovarian carcinoma cells (A2780 and A2780cisR), as well as against nontumorigenic human embryonic kidney (HEK293) cells, and compared to the free ligand and cisplatin. Two of the complexes, that is from the first series with p-cymene and hexamethylbenzene, display relevant activities against the cisplatin-resistant A2780cisR cancer cell line.
引用
收藏
页码：1800 / 1806
页数：7
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