Structure and catalytic activity of some soluble polyethylene glycol-peptide conjugates

被引：25
|
作者：
Kelly, DR
Bui, TTT
Caroff, E
Drake, AF
Roberts, SM
机构：
[1] Cardiff Univ, Dept Chem, Cardiff CF10 3TB, S Glam, Wales
[2] Kings Coll London, Dept Pharm, London SE1 9NN, England
[3] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 20期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/j.tetlet.2004.03.120
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Soluble catalysts for the Julia-Colonna asymmetric epoxidation reaction have been constructed in three different ways, using NH2-PEG-OMe as the support system: suitable solvents have been identified and it is shown that the degree of helicity of the conjugates correlates with the extent of conversion and (to a lesser extent) the enantioselectivity of epoxidation. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3885 / 3888
页数：4
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