Antigen recognition and evolution in a bit-string population model

被引：1
|
作者：
Castiglione, F [1 ]
机构：
[1] Univ Cologne, Ctr Parallel Comp, D-50931 Cologne, Germany
来源：
INTERNATIONAL JOURNAL OF MODERN PHYSICS C | 1999年 / 10卷 / 06期
关键词：
population dynamics; molecular evolution; bit-string models; immune system (IS); Celada-Seiden model (CS-model); hypermutation;
D O I：
10.1142/S0129183199000796
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
We present a simple model of selection and mutation of cell populations in the immune system. This is based on generic assumptions and in this respect it resembles a model for evolution in simple ecosystems. In this case the selection acts by means of the affinity function representing the ability of a certain class of lymphocytes to recognize a foreign antigen. Carrying out some analytical and numerical studies we determine the critical values for the parameters ruling the selection and mutation.
引用
收藏
页码：989 / 1002
页数：14
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