Polyamine blockade promotes antitumor immunity

被引：24

作者：

Hayes, Candace S. ^{[1
]}

Burns, Mark R. ^{[2
]}

Gilmour, Susan K. ^{[1
]}

机构：

[1] Lankenau Inst Med Res, Wynnewood, PA 19096 USA

[2] Aminex Therapeut Inc, Kenmore, WA USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期

关键词：

difluoromethylornithine; immunomodulation; polyamines; transport inhibitor; tumor microenvironment; CELLS; CANCER;

D O I：

10.4161/onci.27360

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The levels of polyamines are elevated in neoplastic lesions as compared with normal tissues, and cancer cells tend to manifest a robust dependence on these compounds for proliferation and survival. We have recently demonstrated that a novel approach to polyamine depletion suppresses tumor growth in a T cell-dependent manner, highlighting a poorly appreciated role of polyamines as strong modulators of antitumor immune responses.

引用

页数：3

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