I2-Mediated Oxidative C-N and N-S Bond Formation in Water: A Metal-Free Synthesis of 4,5-Disubstituted/N-Fused 3-Amino-1,2,4-triazoles and 3-Substituted 5-Amino-1,2,4-thiadiazoles

被引：46

作者：

Jatangi, Nagesh ^{[1
]}

Tumula, Nagaraju ^{[1
]}

Palakodety, Radha Krishna ^{[1
]}

Nakka, Mangarao ^{[1
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Organ & Biomol Chem Div, Hyderabad 500007, Andhra Pradesh, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 10期

关键词：

ONE-POT SYNTHESIS; MOLECULAR-IODINE; ANTIFUNGAL AGENTS; 1,2,4-TRIAZOLES; DERIVATIVES; 1,2,4-THIADIAZOLES; DIMERIZATION; EFFICIENT;

D O I：

10.1021/acs.joc.8b00753

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An environmentally benign and convenient strategy for the synthesis of 4,5-disubstituted/N-fused 3-amino-1,2,4-triazoles and 3-substituted 5-amino-1,2,4-thiadiazoles from isothiocyanates has been developed. This metal-free method involves I-2-mediated oxidative C-N and N-S bond formations in water. Furthermore, this facile protocol exhibited excellent substrate tolerance in good to high yields and scalable fashion.

引用

页码：5715 / 5723

页数：9

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