DREADDs: novel tools for drug discovery and development

被引：70
|
作者：
Lee, Hyeong-Min
Giguere, Patrick M.
Roth, Bryan L. [1 ]
机构：
[1] Univ N Carolina, Div Chem Biol & Med Chem, Chapel Hill Med Sch, Dept Pharmacol, Chapel Hill, NC 27514 USA
来源：
DRUG DISCOVERY TODAY | 2014年 / 19卷 / 04期
关键词：
PROTEIN-COUPLED RECEPTORS; DESIGNED G(I)-COUPLED RECEPTOR; FUNCTIONAL SELECTIVITY; CONDITIONAL EXPRESSION; SEROTONIN RECEPTORS; SIGNAL-TRANSDUCTION; TRANSGENIC MICE; PATHWAYS; LIGANDS; TARGETS;
D O I：
10.1016/j.drudis.2013.10.018
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Since the invention of the first designer receptors exclusively activated by designer drugs (DREADDs), these engineered G protein-coupled receptors (GPCRs) have been widely applied in investigations of biological processes and behaviors. DREADD technology has emerged as a powerful tool with great potential for drug discovery and development. DREADDs can facilitate the identification of druggable targets and enable researchers to explore the activities of novel drugs against both known and orphan GPCRs. Here, we discuss how DREADDs can be used as novel tools for drug discovery and development.
引用
收藏
页码：469 / 473
页数：5
相关论文
共 50 条
  • [41] DRUG DISCOVERY Tools and rules for macrocycles
    Heinis, Christian
    NATURE CHEMICAL BIOLOGY, 2014, 10 (09) : 696 - 698
  • [42] Antibodies as tools to guide drug discovery
    Lawson, A.
    IMMUNOLOGY, 2010, 131 : 23 - 23
  • [43] Computational mapping tools for drug discovery
    Ivanenkov, Yan A.
    Savchuk, Nikolay P.
    Ekins, Sean
    Balakin, Konstantin V.
    DRUG DISCOVERY TODAY, 2009, 14 (15-16) : 767 - 775
  • [44] Bacteriophages as tools in drug discovery programs
    Kurtboke, D. I.
    JOURNAL OF CLINICAL VIROLOGY, 2009, 46 : S13 - S13
  • [45] Target-based drug discovery for the development of novel antiinfectives
    Selzer, PM
    Brutsche, S
    Wiesner, P
    Schmid, P
    Müllner, H
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2000, 290 (02) : 191 - 201
  • [46] A Vision for Drug Discovery and Development: Novel Targets and Multilateral Partnerships
    Roger S. McIntyre
    Advances in Therapy, 2014, 31 : 245 - 246
  • [47] A Vision for Drug Discovery and Development: Novel Targets and Multilateral Partnerships
    McIntyre, Roger S.
    ADVANCES IN THERAPY, 2014, 31 (03) : 245 - 246
  • [48] Novel MicroScale Solutions for Biophysical Characterization in Drug Discovery and Development
    Heffern, Charles
    FASEB JOURNAL, 2017, 31
  • [49] Example of drug discovery program leading to the development of novel reactions
    Dai, Xing
    Miller, Michael
    Stamford, Andrew
    DeMong, Duane
    Yu, Wensheng
    Wong, Michael
    Lavey, Brian
    Greenlee, William
    Kozlowski, Joseph
    Lin, Sue-Ing
    Zhou, Guowei
    Yang, De-Yi
    Hwa, Joyce
    Kang, Ling
    Lachowicz, Jean
    Soriano, Aileen
    Zhai, Ying
    Patel, Bhuneshwari
    Zhang, Hongtao
    Grotz, Diane
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [50] Development of novel DDS technologies for pharmacoproteomic-based drug discovery and development
    Tsutsumi, Y
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2004, 124 (11): : 769 - 780
12345