Of seeds and supplements: structural insights into extended microRNA-target pairing

被引：2
|
作者：
Fabian, Marc R. [1 ,2 ,3 ]
机构：
[1] McGill Univ, Dept Oncol, Montreal, PQ, Canada
[2] McGill Univ, Dept Biochem, Montreal, PQ, Canada
[3] Jewish Gen Hosp, Segal Canc Ctr, Lady Davis Inst Med Res, Montreal, PQ, Canada
来源：
EMBO JOURNAL | 2019年 / 38卷 / 13期
关键词：
ARGONAUTE; GUIDE;
D O I：
10.15252/embj.2019102477
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metazoan micro(mi) RNAs guide Argonaute proteins to their targets via perfect pairing to the seed region, located near the 5 ' end of the miRNA. In this issue of The EMBO Journal, Sheu-Gruttadauria et al report the crystal structure of human Argonaute 2 in complex with both a miRNA and target RNA and show that miRNA 3 ' supplementary nucleotides can increase target affinity and may contribute more to miRNA-mediated silencing than is currently appreciated.
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页数：3
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