Palladium-Catalyzed Intermolecular Aryldifluoroalkylation of Alkynes

被引：102
|
作者：
He, Yu-Tao [1 ]
Wang, Qiang [1 ]
Li, Lian-Hua [1 ]
Liu, Xue-Yuan [1 ]
Xu, Peng-Fei [1 ]
Liang, Yong-Min [1 ,2 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 21期
关键词：
ARYL BORONIC ACIDS; MEDIATED RADICAL ARYLDIFLUOROACETYLATION; OXIDATIVE TRIFLUOROMETHYLATION; ETHYL BROMODIFLUOROACETATE; UNACTIVATED ALKENES; BOND-FORMATION; DIFLUOROMETHYLATION; HYDROTRIFLUOROMETHYLATION; DIFLUOROACETYLATION; DIFLUOROALKYLATION;
D O I：
10.1021/acs.orglett.5b02512
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed aryldifluoroalkylation of alkynes with ethyl difluoroiodoacetate and arylboronic acids as reaction partners is described. The alkyne difunctionalization process provides various aryldifluoroalkylated products in one pot under mild reaction conditions. A wide range of alkynes and diverse arylboronic acids are compatible with these reaction conditions. High reaction efficiency and broad substrate scope are the notable features of this transformation. Preliminary mechanistic investigations indicate that a difluoroalkyl radical addition pathway is involved in this transformation.
引用
收藏
页码：5188 / 5191
页数：4
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