Open-vessel microwave-promoted Suzuki reactions using low levels of palladium catalyst: Optimization and scale-up

被引：60
|
作者：
Leadbeater, Nicholas E.
Williams, Victoria A.
Barnard, Thomas M.
Collins, Michael J., Jr.
机构：
[1] Univ Connecticut, Dept Chem, Unit 3060, Storrs, CT 06269 USA
[2] CEM Microwave Technol, Matthews, NC 28104 USA
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2006年 / 10卷 / 04期
关键词：
D O I：
10.1021/op0600613
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Representative Suzuki couplings in water using low catalyst concentrations in conjunction with microwave heating have been transferred from sealed-vessel to open-vessel reaction conditions. They have then been scaled-up to the mole scale using a dedicated multimode microwave apparatus. The reactions are complete within 20 min of heating at reflux.
引用
收藏
页码：833 / 837
页数：5
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