Solvent-free, open-vessel microwave-promoted Heck couplings: From the mmol to the mol scale

被引：26
|
作者：
Leadbeater, Nicholas E.
Williams, Victoria A.
Barnard, Thomas M.
Collins, Michael J., Jr.
机构：
[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA
[2] CEM Microwave Technol, Matthews, NC 28104 USA
来源：
SYNLETT | 2006年 / 18期
关键词：
palladium; Heck reaction; catalysis; solvent-free; microwave;
D O I：
10.1055/s-2006-951512
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The rapid, microwave-promoted Heck coupling of aryl iodides in open reaction vessels is presented and scale-up of the reactions to the mol scale demonstrated. Reactions are performed using 0.1 mol% palladium acetate as the catalyst, sodium carbonate and tributylamine as bases and tetrabutylanimonium bromide as an additive.
引用
收藏
页码：2953 / 2958
页数：6
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