Copper-free synthesis of skipped diynes via cross-coupling reactions of alkynylalanes with propargylic electrophiles

被引：13

作者：

Kessabi, Jilali ^{[1
]}

Beaudegnies, Renaud ^{[1
]}

Jung, Pierre M. J. ^{[1
]}

Martin, Benjamin ^{[1
]}

Montel, Florian ^{[1
]}

Wendeborn, Sebastian ^{[1
]}

机构：

[1] SYNGENTA Crop Protect AG, Res Chem, CH-4002 Basel, Switzerland

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 24期

关键词：

D O I：

10.1021/ol0623769

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkynylalanes provide a new, copper-free route to skipped diynes when combined with propargylic electrophiles bearing an aluminum-complexing leaving group. The reaction is mild, efficient, and, in contrast to copper- mediated methods, highly regioselective.

引用

页码：5629 / 5632

页数：4

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