Copper-free synthesis of skipped diynes via cross-coupling reactions of alkynylalanes with propargylic electrophiles

被引：13
|
作者：
Kessabi, Jilali [1 ]
Beaudegnies, Renaud [1 ]
Jung, Pierre M. J. [1 ]
Martin, Benjamin [1 ]
Montel, Florian [1 ]
Wendeborn, Sebastian [1 ]
机构：
[1] SYNGENTA Crop Protect AG, Res Chem, CH-4002 Basel, Switzerland
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 24期
关键词：
D O I：
10.1021/ol0623769
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Alkynylalanes provide a new, copper-free route to skipped diynes when combined with propargylic electrophiles bearing an aluminum-complexing leaving group. The reaction is mild, efficient, and, in contrast to copper- mediated methods, highly regioselective.
引用
收藏
页码：5629 / 5632
页数：4
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