Synthesis of 3-alkylideneisoindolinones and isoindolones by a Horner-Wadsworth-Emmons reaction

被引：16

作者：

Angel Reyes-Gonzalez, Miguel ^{[1
]}

Zamudio-Medina, Angel ^{[1
]}

Abelardo Ramirez-Marroquin, Oscar ^{[1
]}

Ordonez, Mario ^{[1
]}

机构：

[1] Univ Autonoma Estado Morelos, Ctr Invest Quim, Cuernavaca, Morelos, Mexico

来源：

MONATSHEFTE FUR CHEMIE | 2014年 / 145卷 / 06期

关键词：

Phosphonates; Three-component reaction; Wittig reaction; Heterocycles; ISOINDOLINONE DERIVATIVES; STEREOSELECTIVE-SYNTHESIS; EFFICIENT SYNTHESIS; INHIBITORY-ACTIVITY; POTENT INHIBITORS; CYCLIZATION; NITROGEN; ANALOG; LENNOXAMINE; DISCOVERY;

D O I：

10.1007/s00706-013-1146-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 3-alkylideneisoindolinones was prepared by a Horner-Wadsworth-Emmons (HWE) reaction of aromatic aldehydes with N-(omega-hydroxyalkyl)substituted 3-phosphoisoindolin-1-ones, obtained in one-pot synthesis from 2-formylbenzoic acid. Additionally, the intramolecular HWE reaction of the N-(omega-formylalkyl)substituted phosphoisoindolin-1-ones afforded the corresponding isoindolone derivatives.

引用

页码：1001 / 1007

页数：7

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